Endocrine Abstracts

Introduction and purpose: Acromegaly is characterised by a chronic increase of GH and IGF-1 levels that may induce various clinical symptoms and multisystem comorbidities. The purpose of this study is to evaluate the type and frequency of thyroid disease most often associated with acromegaly patients.Material and methods: We conducted a retrospective observational study analysing the data from the observation charts of 77 patients with acromegaly (58 fem...

Introduction: Combined pituitary hormone deficiency (CPHD) is characterized by impaired production of pituitary hormones. A possible cause are PROP-1 mutations (prophet of Pit-1 protein). It plays an essential role in the evolution of pituitary cells secreting GH, TSH, LH, FSH, prolactin; some patients may develop late ACTH deficiency. PROP 1 gene mutation is manifested with variable degrees of phenotype-genotype correlation, with growth failure as the first sign detected in e...

Introduction: Obesity caused health problems are increasing. Metabolic syndrome including obesity with insulin resistance, hypertension, and high blood lipid levels increases the risks of cardiovascular and inflammatory diseases. Many studies have reported that heme oxygenase (HO) inducers reduce insulin resistance and severity of inflammatory bowel disease. We investigate the anti-inflammatory effect, one among many positive effects, of regular recreational physical activity ...